Case study: MSIntuit® CRC
Authors
Testimonial
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A pre-screen approach for MSI from digitized H&E slides
Context
Microsatellite instability (MSI) is a genomic biomarker that plays an important role in the treatment of colorectal tumours (CRC) patients. MSI is predictive of response to immunotherapy across all solid tumors.
Methods
We developed MSIntuit, an AI based pre-screening tool for MSI detection of CRC from H&E WSI, and performed the first successful blind validation confirming its robustness for clinical applications.
Results
MSIntuit CRC reaches sensitivity comparable to gold standard methods (92-95%) while ruling out almost half of the MSS patients.
MSIntuit CRC is an interpretable model - it highlights the parts of the slide image used to make its predictions.
Impact
With a sensitivity of ~95%, MSIntuit CRC can help rule out 40% of CRC patients from reflex screening with standard MMR/MSI testing techniques.
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